CT M.A.R.S. CZECH VERSION CLINICAL TRIAL M.A.R.S. M.A.R.S. is a randomized, double-blind, placebo-controlled, multicenter study of the efficacy and safety of highly diluted atropine eye drops in slowing the progression of myopia in children,  a phase IIIb, three parallel-arm study designed to increase clinical knowledge of the effect of topical application of highly diluted atropine…
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CT MSC-EB CZECH VERSION CLINICAL TRIAL MSC-EB Safety and efficacy of allogenic adipose tissue-derived mesenchymal stromal cells in patients with epidermolysis bullosa: clinical trial phase I/II MSC-EB is a phase I/II clinical trial aiming to evaluate the safety and efficacy of the mesenchymal stromal cell-based medicinal product in patients with the rare congenital (genetic) disease…
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CT KDO_DC1311 CZECH VERSION CLINICAL TRIAL KDO_DC1311 Combined antitumor therapy with ex vivo manipulated dendritic cells producing interleukin-12 in children, adolescents and young adults with progressive, recurrent or primarily metastatic high-risk tumors KDO_DC1311 is a phase I/II clinical trial aiming to evaluate the safety and efficacy of the dendritic cell-based medicinal product in children, adolescent…
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CT CoVigi CZECH VERSION CLINICAL TRIAL CoVigi CoVigi is a multi-centre, phase IV post-marketing intervention trial that aims to monitor long-term safety and efficacy after vaccination against COVID-19. The trial was initiated by Masaryk University in cooperation with the University Hospital Brno and the Masaryk Memorial Cancer Institute. A total of 559 patients were enrolled…
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CT DisCoVeRy CZECH VERSION CLINICAL TRIALS DisCoVeRy A multicenter, adaptive, randomized study of safety and efficacy in hospitalized adult patients with COVID-19. The treatment of COVID-19 is still a major challenge for medical research, so new drugs are being explored or the use of existing drugs is being optimized. One of the new medicines is…
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CT HALF CZECH VERSION CLINICAL TRIAL HALF Prospective phase II clinical trial evaluating the efficacy and safety of tyrosine kinase inhibitor discontinuation after prior two-step dose reduction in patients with chronic myeloid leukemia in deep molecular remission The HALF clinical trial is designed as a prospective, multicentre, non-randomized, open-label phase II study to investigate the…
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CT REMED CZECH VERSION CLINICAL TRIAL REMED Effect of dexamethasone in patients with ARDS and COVID-19 – prospective, multi-centre, open-label, parallel-group, randomized controlled trial (REMED trial). COVID-19 is still a significant challenge for medical research, exploring new drugs or possible optimizing the use of existing drugs. One way to use an existing medicine is to…
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CT SolidAct CZECH VERSION CLINICAL TRIAL SolidAct European DisCoVeRy for Solidarity (EU-SolidAct): Clinical study with adaptive platform design for pandemics and new infections Within the platform design, the study follows a generic main protocol, to which a drug-specific sub-protocol is always added. So far, there are two arms in the EU-SolidAct study: 1. Sub-protocol Bari-SolidAct…
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