The Pediatric Clinical Research Infrastructure Service Model (PRISM) is a European consortium whose goal is to strengthen the conduct of international pediatric research by providing infrastructure and expert support for investigator-initiated academic studies.
The PRISM project is funded by the Horizon Europe program (GA101292607). Through a two-stage selection process, it selects pilot pediatric clinical trials and provides comprehensive support—from design through implementation—for international academic studies conducted in 3 to 6 countries across Europe and Canada.
Shortlisted projects receive targeted support from the PRISM consortium in preparing the study design and planning the complete application.
Following a final evaluation, selected projects will receive funding to cover the costs associated with conducting and coordinating the study, as well as services for managing the international clinical trial provided by the PRISM consortium.
Key Information
- Eligible studies: pragmatic, researcher-initiated randomized controlled clinical trials comparing or optimizing healthcare strategies (therapeutic, diagnostic, or preventive interventions) and prospective observational cohort studies.
- Study population: children from birth to 18 years of age. All areas of pediatric diseases may be included, with the exception of oncology and rare diseases.
- Participant recruitment: in 3 to 6 countries in Europe (EU, Norway, Switzerland, United Kingdom) and Canada, at a maximum of 15 centers (with the exception of cluster-randomized controlled trials).
- Maximum study duration: 30 months from study initiation to the final center visit.
- Required budget: 1–2 million EUR for interventional studies or up to 1 million EUR for observational studies, including the mandatory ECRIN Coordinated Service Package.
- The study must have a single experienced non-commercial sponsor, or a sponsor representative where required.
Before submitting your application, please carefully read the entire text of the call for proposals and the guidelines for applicants.
More information and documents related to the call for proposals: https://prismeu.org/calls.html
Inquiries:PRISM Joint Call Secretariat – call2026@prismeu.org
+ English version
PRISM Call for Proposals on Multinational, Investigator-Initiated Pediatric Clinical Studies
The Paediatric Clinical Research Infrastructure Service Model (PRISM) is a European consortium aiming to strengthen the conduct of multinational pediatric research by providing infrastructure and expertise to investigator-initiated studies.
Funded by Horizon Europe (GA101292607), PRISM selects, through a two-stage process, pilot pediatric clinical studies to provide comprehensive, end-to-end support for multinational investigator-initiated studies conducted in 3 to 6 countries in Europe and Canada.
Shortlisted projects receive dedicated support from the PRISM consortium during the design and planning of the full application.
Following final assessment, selected projects receive funding to cover the costs of investigation and trial coordination, as well as multinational trial management services provided by the PRISM consortium.
Key Details
- Eligible studies: pragmatic, investigator-initiated randomized controlled trials comparing or optimizing healthcare strategies (therapeutic, diagnostic, or preventive interventions), and prospective observational cohort studies.
- Study population: birth to 18 years of age. Any pediatric disease area except oncology and rare diseases.
- Recruitment: in 3 to 6 countries across Europe (EU, Norway, Switzerland, United Kingdom) and Canada, with a maximum of 15 sites (except for cluster randomized controlled trials).
- Maximum study duration: 30 months, from study start-up to the close-out visit.
- Requested budget: 1–2 M€ for interventional studies, or up to 1 M€ for observational studies, including the mandatory ECRIN Coordinated Service Package.
- A single, non-commercial, experienced sponsor, with a sponsor representative when required.
Please read the call text and application guidelines in full before applying.
Questions: PRISM Joint Call Secretariat – call2026@prismeu.org