CZECRIN is the key infrastructure supporting the implementation of academic clinical research in the Czech Republic. CZECRIN, as the national node of Clinical Research Infrastructures of the European Network ECRIN-ERIC, makes a fundamental contribution to academic institutions’ involvement in international clinical research projects. LRI CZECRIN was built as a unique infrastructure, involving the network of most major clinical sites with a focus on clinical research and providing knowledge, development, production, and implementation capacities in the field of research and development of drugs and medical devices. CZECRIN set up advanced solutions for the effective provisioning and use of high-quality scientific data, fully implementing the FAIR (Findable, Accessible, Interoperable, and Reusable) principles. CZECRIN is also a center for education in clinical trials.