{"id":9072,"date":"2021-01-29T11:26:00","date_gmt":"2021-01-29T10:26:00","guid":{"rendered":"https:\/\/czecrin.cz\/project\/kh-seotp\/"},"modified":"2026-01-06T10:02:40","modified_gmt":"2026-01-06T09:02:40","slug":"kh-seotp","status":"publish","type":"project","link":"https:\/\/czecrin.cz\/en\/project\/kh-seotp\/","title":{"rendered":"KH SEOTP"},"content":{"rendered":"\n<h3 class=\"wp-block-heading has-text-align-center\">SEOTP &#8211; Safety and efficacy of olanzapine therapy in psychosis: influence of genetic and epigenetic factors &#8211; covariates of treatment response<\/h3>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-black-color has-alpha-channel-opacity has-black-background-color has-background\"\/>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\">SEOTP is a phase IV clinical trial to improve and innovate existing treatment approaches for psychosis based on genotype and endophenotype, including pharmacokinetic analysis, to minimise the adverse effects of olanzapine treatment and to gain further insights into the efficacy of this treatment.<\/p>\n\n\n\n<p class=\"has-text-align-center\">The sponsor of the clinical trial is Masaryk University. The patients participating in the trial are under the care of the principal investigators, Prof. Libor Ustohal, M.D., Ph.D., from the Psychiatric Clinic of the University Hospital Brno and Petr \u0160ilh\u00e1n, M.D., Ph.D., from the Psychiatric Department of the University Hospital Ostrava, and their colleagues.   <\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>Patient recruitment<\/strong><br>Clinical trials have been initiated in all participating centres but have not yet started. Of the total number of patients planned to be enrolled (200), 0 patients are currently enrolled. <\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong>Contact<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\">National Coordinator of SEOTP<br>doc. PharmDr. Jan Ju\u0159ica, Ph.D.  <\/p>\n\n\n\n<p class=\"has-text-align-center\">Project Manager<br>Ing. Karol\u00edna Grodov\u00e1 | <strong><a href=\"mailto:karolina.grodova@med.muni.cz\">karolina.grodova@med.muni.cz<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/czecrin.cz\/wp-content\/uploads\/2025\/04\/SEOTP_souhrn-protokolu_v4.1_27.03.2023.pdf\" style=\"color:#2948f1;background-color:#71d8ff\" target=\"_blank\" rel=\"noreferrer noopener\">Protocol summary<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/euclinicaltrials.eu\/search-for-clinical-trials\/?lang=en\" style=\"color:#2948f1;background-color:#60e67b\" target=\"_blank\" rel=\"noreferrer noopener\">EU-Clinical Trials Register<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h6 class=\"wp-block-heading has-text-align-center\">Patient recruitment<\/h6>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"415\" src=\"https:\/\/czecrin.cz\/wp-content\/uploads\/2021\/01\/SEOTP-2-1024x415.png\" alt=\"\" class=\"wp-image-9327\" srcset=\"https:\/\/czecrin.cz\/wp-content\/uploads\/2021\/01\/SEOTP-2-980x397.png 980w, https:\/\/czecrin.cz\/wp-content\/uploads\/2021\/01\/SEOTP-2-480x194.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>SEOTP &#8211; Safety and efficacy of olanzapine therapy in psychosis: influence of genetic and epigenetic factors &#8211; covariates of treatment response SEOTP is a phase IV clinical trial to improve and innovate existing treatment approaches for psychosis based on genotype and endophenotype, including pharmacokinetic analysis, to minimise the adverse effects of olanzapine treatment and to [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"project_category":[147,169],"project_tag":[162,170],"class_list":["post-9072","project","type-project","status-publish","hentry","project_category-national-research-projects","project_category-planned-and-upcoming-clinical-trials","project_tag-phase-iv","project_tag-psychiatry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>KH SEOTP &#8226; 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